Table 3.
Associations of interleukin genetic polymorphisms (dominant model) with gastric cancer risk
| Gene | rs No. | No. (%) |
OR (95% CI) |
|||
|---|---|---|---|---|---|---|
| Control | Case | Control | Fully adjusteda) | |||
| IL10 | rs1800871 | AA | 368 (48.81) | 173 (45.89) | 1 | 1 |
| G+ | 386 (51.19) | 204 (54.11) | 1.12 (0.88-1.44) | 1.06 (0.80-1.41) | ||
| IL2 | rs2069763 | AA | 226 (29.97) | 1111 (29.44) | 1 | 1 |
| C+ | 528 (70.03) | 266 (70.56) | 1.03 (0.78-1.35) | 1.19 (0.88-1.62) | ||
| rs2069762 | AA | 358 (47.73) | 165 (43.77) | 1 | 1 | |
| C+ | 392 (52.27) | 212 (56.23) | 1.17 (0.92-1.51) | 1.23 (0.93-1.64) | ||
| IL13 | rs6596090 | GG | 517 (70.24) | 255 (69.29) | 1 | 1 |
| A+ | 219 (29.76) | 113 (30.71) | 1.05 (0.80-1.37) | 1.04 (0.77-1.43) | ||
| rs20541 | GG | 366 (48.54) | 185 (49.07) | 1 | 1 | |
| A+ | 388 (51.46) | 192 (50.93) | 0.98 (0.76-1.25) | 0.86 (0.65-1.14) | ||
| IL4R | rs7205663 | TT | 259 (34.35) | 126 (33.42) | 1 | 1 |
| C+ | 495 (65.65) | 251 (66.58) | 1.04 (0.80-1.35) | 0.99 (0.73-1.33) | ||
| rs1805010 | GG | 253 (33.55) | 126 (33.42) | 1 | 1 | |
| A+ | 501 (66.45) | 251 (66.58) | 1.01 (0.77-1.31) | 0.95 (0.70-1.28) | ||
OR, odds ratio; CI, confidence interval.
a)
Adjusted by education, alcohol consumption, smoking status, Helicobacter pylori infection, and regular exercise.