Table 4.
Associations and interaction of interleukin genetic polymorphisms (dominant model) and non-fermented soy intake with gastric cancer risk stratified by histological type
| Gene SNP | Allele group | Soy intake | All types |
Intestinal |
Diffuse |
Mixed |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. (%) |
OR (95% Cl) |
pinteraction | No. (%) |
OR (95% Cl) |
pinteraction | No. (%) |
OR (95% Cl) |
pinteraction | No. (%) |
OR (95% Cl) |
pinteraction | ||||||||
| Control | Case | Crude | Fully adjusteda) | Control | Case | Fully adjusteda) | Control | Case | Fully adjusteda) | Control | Case | Fully adjusteda) | |||||||
| IL10 rs1800871 | |||||||||||||||||||
| AA | Low | 185 (50.27) | 112 (64.74) | 1 | 1 | 0.342 | 65 (48.87) | 42 (70.00) | 1 | 0.033 | 80 (51.28) | 43 (56.58) | 1 | 0.226 | 24 (48.00) | 15 (68.18) | 1 | 0.525 | |
| High | 183 (49.73) | 61 (35.26) | 0.55 (0.38 -0.80) | 0.50 (0.33 -0.77) | 68 (51.13) | 18 (30.00) | 0.34 (0.16 -0.74) | 76 (48.72) | 33 (43.42) | 0.69 (0.37 -1.31) | 26 (52.00) | 7 (31.82) | 0.46 (0.14 -1.46) | ||||||
| G+ | Low | 192 (49.74) | 131 (64.22) | 1 | 1 | 81 (52.26) | 47 (55.95) | 1 | 64 (43.84) | 52 (69.33) | 1 | 28 (50.00) | 20 (64.52) | 1 | |||||
| High | 194 (50.26) | 73 (35.78) | 0.55 (0.39 -0.78) | 0.70 (0.47 -1.04) | 74 (47.74) | 37 (44.05) | 0.98 (0.53 -1.82) | 82 (56.16) | 23 (30.67) | 0.44 (0.23 -0.88) | 28 (50.00) | 11 (35.48) | 0.71 (0.23 -2.17) | ||||||
| IL2 rs2069763 | |||||||||||||||||||
| AA | Low | 120 (53.10) | 69 (62.16) | 1 | 1 | 0.344 | 43 (53.75) | 21 (51.22) | 1 | 0.157 | 52 (51.49) | 24 (63.16) | 1 | 0.391 | 14 (48.28) | 15 (65.22) | 1 | 0.982 | |
| High | 106 (46.90) | 42 (37.84) | 0.69 (0.43 -1.10) | 0.75 (0.44 -1.29) | 37 (46.25) | 20 (48.78) | 1.23 (0.51 -2.97) | 49 (48.51) | 14 (36.84) | 0.77 (0.31 -1.94) | 15 (51.72) | 8 (34.78) | 0.42 (0.10 -1.86) | ||||||
| C+ | Low | 257 (48.67) | 174 (65.41) | 1 | 1 | 103 (49.52) | 68 (66.02) | 1 | 92 (45.77) | 71 (62.83) | 1 | 38 (49.35) | 20 (66.67) | 1 | |||||
| High | 271 (51.33) | 92 (34.59) | 0.50 (0.37 -0.68) | 0.53 (0.37 -0.75) | 105 (50.48) | 35 (33.98) | 0.48 (0.27 -0.86) | 109 (54.23) | 42 (37.17) | 0.45 (0.26 -0.78) | 39 (50.65) | 10 (33.33) | 0.66 (0.24 -1.81) | ||||||
| IL2 rs2069762 | |||||||||||||||||||
| AA | Low | 184 (51.40) | 99 (60.00) | 1 | 1 | 0.039 | 77 (53.47) | 30 (47.62) | 1 | 0.001 | 67 (47.86) | 41 (64.06) | 1 | 0.626 | 23 (51.11) | 19 (67.86) | 1 | 0.998 | |
| High | 174 (48.60) | 66 (40.00) | 0.71 (0.49 -1.03) | 0.84 (0.54 -1.29) | 67 (46.53) | 33 (52.38) | 1.54 (0.76 -3.10) | 73 (52.14) | 23 (35.94) | 0.63 (0.61 -1.30) | 22 (48.89) | 9 (32.14) | 0.44 (0.13 -1.44) | ||||||
| C+ | Low | 192 (48.98) | 144 (67.92) | 1 | 1 | 69 (48.25) | 59 (72.84) | 1 | 76 (47.50) | 54 (62.07) | 1 | 29 (48.33) | 16 (64.00) | 1 | |||||
| High | 200 (51.02) | 68 (32.08) | 0.45 (0.32 -0.64) | 0.46 (0.31 -0.68) | 74 (51.75) | 22 (27.16) | 0.28 (0.14 -0.57) | 84 (52.50) | 33 (37.93) | 0.50 (0.27 -0.92) | 31 (51.67) | 9 (36.00) | 0.72 (0.23 -2.28) | ||||||
| IL13 rs6596090 | |||||||||||||||||||
| GG | Low | 270 (52.22) | 169 (66.27) | 1 | 1 | 0.972 | 108 (53.20) | 60 (65.22) | 1 | 0.677 | 101 (49.75) | 63 (62.38) | 1 | 0.856 | 36 (51.43) | 30 (71.43) | 1 | 0.919 | |
| High | 247 (47.78) | 86 (33.73) | 0.56 (0.41 -0.76) | 0.58 (0.41 -0.82) | 95 (46.80) | 32 (34.78) | 0.56 (0.31 -1.01) | 102 (50.25) | 38 (37.62) | 0.56 (0.32 -0.97) | 34 (48.57) | 12 (28.57) | 0.58 (0.22 -1.54) | ||||||
| A+ | Low | 102 (46.58) | 71 (62.83) | 1 | 1 | 37 (48.05) | 27 (57.45) | 1.00 | 40 (43.48) | 31 (64.58) | 1.00 | 15 (45.45) | 5 (55.56) | 1.00 | |||||
| High | 117 (53.42) | 42 (37.17) | 0.52 (0.32 -0.82) | 0.60 (0.35 -1.04) | 40 (51.95) | 20 (42.55) | 0.69 (0.27 -1.73) | 52 (56.52) | 17 (35.42) | 0.48 (0.20 -1.14) | 18 (54.55) | 4 (44.44) | 0.65 (0.09 -4.79) | ||||||
| IL13 rs20541 | |||||||||||||||||||
| GG | Low | 187 (51.09) | 119 (64.32) | 1 | 1 | 0.549 | 72 (52.17) | 40 (62.50) | 1 | 0.922 | 74 (48.37) | 50 (62.50) | 1 | 0.724 | 28 (54.90) | 17 (65.38) | 1 | 0.050 | |
| High | 179 (48.91) | 66 (35.68) | 0.58 (0.40 -0.83) | 0.63 (0.42 -0.96) | 66 (47.83) | 24 (37.50) | 0.63 (0.31 -1.27) | 79 (51.63) | 30 (37.50) | 0.48 (0.25 -0.91) | 23 (45.10) | 9 (34.62) | 1.74 (0.42 -7.16) | ||||||
| A+ | Low | 190 (48.97) | 124 (64.58) | 1 | 1 | 74 (49.33) | 49 (61.25) | 1.00 | 70 (46.98) | 45 (的.38) | 1.00 | 24 (43.64) | 18 (66.67) | 1.00 | |||||
| High | 198 (51.03) | 68 (35.42) | 0.53 (0.37 -0.75) | 0.55 (0.37 -0.82) | 76 (50.67) | 31 (38.75) | 0.65 (0.34 -1.26) | 79 (53.02) | 26 (36.62) | 0.60 (0.31 -1.18) | 31 (56.36) | 9 (33.33) | 0.27 (0.09 -0.85) | ||||||
| IL4R rs7205663 | |||||||||||||||||||
| TT | Low | 129 (49.81) | 83 (65.87) | 1 | 1 | 0.955 | 54 (52.94) | 31 (64.58) | 1 | 0.592 | 43 (44.33) | 33 (64.71) | 1 | 0.710 | 16 (45.71) | 14 (73.68) | 1 | 0.660 | |
| High | 130 (50.19) | 43 (34.13) | 0.51 (0.33 -0.80) | 0.60 (0.36 -1.00) | 48 (47.06) | 17 (35.42) | 0.53 (0.23 -1.22) | 54 (55.67) | 18 (35.29) | 0.52 (0.23 -1.17) | 19 (54.29) | 5 (26.32) | 0.51 (0.08 -3.11) | ||||||
| C+ | Low | 248 (50.10) | 160 (63.75) | 1 | 1 | 92 (49.46) | 58 (60.42) | 1 | 101 (49.27) | 62 (62.00) | 1.00 | 36 (50.70) | 21 (61.76) | 1.00 | |||||
| High | 247 (49.90) | 91 (36.25) | 0.57 (0.42 -0.78) | 0.61 (0.43 -0.87) | 94 (50.54) | 38 (39.58) | 0.70 (0.39 -1.26) | 104 (50.73) | 38 (38.00) | 0.59 (0.34 -1.04) | 35 (49.30) | 13 (38.24) | 0.58 (0.22 -1.57) | ||||||
| IL4R rs1805010 | |||||||||||||||||||
| GG | Low | 123 (48.62) | 84 (66.67) | 1 | 1 | 0.400 | 52 (52.00) | 33 (68.75) | 1 | 0.129 | 45 (46.39) | 28 (59.57) | 1 | 0.827 | 14 (40.00) | 16 (76.19) | 1 | 0.288 | |
| High | 130 (51.38) | 42 (33.33) | 0.47 (0.30 -0.74) | 0.51 (0.31 -0.85) | 48 (48.00) | 15 (31.25) | 0.37 (0.16 -0.88) | 52 (53.61) | 19 (40.43) | 0.63 (0.28 -1.42) | 21 (60.00) | 5 (23.81) | 0.29 (0.06 -1.46) | ||||||
| A+ | Low | 254 (50.70) | 159 (63.35) | 1 | 1 | 94 (50.00) | 56 (58.33) | 1 | 99 (48.29) | 67 (64.42) | 1 | 38 (53.52) | 19 (59.38) | 1 | |||||
| High | 247 (49.30) | 92 (36.65) | 0.60 (0.44 -0.81) | 0.66 (0.46 -0.94) | 94 (50.00) | 40 (41.67) | 0.84 (0.47 -1.51) | 106 (51.71) | 37 (35.58) | 0.55 (0.31 -0.97) | 33 (46.48) | 13 (40.63) | 0.79 (0.29 -2.13) | ||||||
Criteria for high and low non-fermented soy product intake groups (total calorie intake adjusted, g/day): low ≤ 64.51, high > 64.51. OR, odds ratio; CI, confidence interval.
a)
Adjusted by age, sex, education, alcohol consumption, smoking status, Helicobacter pylori infection, and regular exercise.