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. 2017 Oct 19;8:1345. doi: 10.3389/fimmu.2017.01345

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Copyright © 2017 Jia, Shan, Pan, Feng, Lv, Sun, Li, Wu, Zhang, Chen, Diana, Sun and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CB0313.1 changes cytokine profiles and induces Tregs in the MLN. (A) Percent IFN-γ⁺ in CD4⁺ cells in MLN as indicated at 13 weeks of age. (B) Percent IL-4⁺ in CD4⁺ cells in MLN as indicated at 13 weeks of age, and protein level of IL-4 determined by ELISA at 13 weeks of age. (C) Percent IL-17A⁺ in CD4⁺ cells in MLN as indicated at 13 weeks of age, and protein level of IL-17A determined by ELISA at 13 weeks of age. (D) Percent Foxp3⁺ in CD4⁺ cells, percent CD4⁺Foxp3⁺ in α4β7⁺ cells in MLN as indicated at 6 weeks of age, and protein levels of TGF-β, IL-10 determined by ELISA at 13 weeks of age. (E) Percent Foxp3⁺ in CD4⁺ cells in MLN as indicated at 9, 13 weeks of age. Data are mean ± SEM (n = 5–9 mice per group). *, **, *** p < 0.05, p < 0.01, p < 0.001 vs NOD control mice by t-test. For (A–C,E), the number of cells is 5,000; For (D), the number of cells is 10,000.

CB0313.1 changes cytokine profiles and induces Tregs in the MLN. (A) Percent IFN-γ⁺ in CD4⁺ cells in MLN as indicated at 13 weeks of age. (B) Percent IL-4⁺ in CD4⁺ cells in MLN as indicated at 13 weeks of age, and protein level of IL-4 determined by ELISA at 13 weeks of age. (C) Percent IL-17A⁺ in CD4⁺ cells in MLN as indicated at 13 weeks of age, and protein level of IL-17A determined by ELISA at 13 weeks of age. (D) Percent Foxp3⁺ in CD4⁺ cells, percent CD4⁺Foxp3⁺ in α4β7⁺ cells in MLN as indicated at 6 weeks of age, and protein levels of TGF-β, IL-10 determined by ELISA at 13 weeks of age. (E) Percent Foxp3⁺ in CD4⁺ cells in MLN as indicated at 9, 13 weeks of age. Data are mean ± SEM (n = 5–9 mice per group). *, **, *** p < 0.05, p < 0.01, p < 0.001 vs NOD control mice by t-test. For (A–C,E), the number of cells is 5,000; For (D), the number of cells is 10,000.