Figure 7.

FTY720 suppresses the accumulation of α4β7⁺ Tregs but not the total Tregs in the PLN. (A) Percent CD4⁺Foxp3⁺ in CD4⁺ spleen cells. (B) Percent CD4⁺ Foxp3⁺ in CD4⁺ MLN cells. (C) Percent CD4⁺Foxp3⁺ in α4β7⁺ MLN cells. (D) Percent CD4⁺Foxp3⁺ in CD4⁺ PLN cells. (E) Percent CD4⁺Foxp3⁺ in α4β7⁺ PLN cells. Data are mean ± SEM (n = 5–8 mice per group). *, **, *** p < 0.05, p < 0.01, p < 0.001 vs NOD control mice by t-test. The number of cells is 10,000–300,000.