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. 2017 Oct 19;8:1345. doi: 10.3389/fimmu.2017.01345

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Copyright © 2017 Jia, Shan, Pan, Feng, Lv, Sun, Li, Wu, Zhang, Chen, Diana, Sun and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CB0313.1 changes the splenic cytokine profiles. (A) Percent CD4⁺Foxp3⁺ cells in spleen as indicated at 6, 9, 13, and 45 weeks of age. Percent CD4⁺IFN-γ⁺ (B) CD4⁺IL-4⁺ (C) and CD4⁺IL-17A⁺ (D) cells in spleen as indicated. Data are mean ± SEM (n = 3–21 mice per group). *, **, *** p < 0.05, p < 0.01, p < 0.001 vs NOD control mice by t-test. The number of cells is 10,000.

CB0313.1 changes the splenic cytokine profiles. (A) Percent CD4⁺Foxp3⁺ cells in spleen as indicated at 6, 9, 13, and 45 weeks of age. Percent CD4⁺IFN-γ⁺ (B) CD4⁺IL-4⁺ (C) and CD4⁺IL-17A⁺ (D) cells in spleen as indicated. Data are mean ± SEM (n = 3–21 mice per group). *, **, *** p < 0.05, p < 0.01, p < 0.001 vs NOD control mice by t-test. The number of cells is 10,000.