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. 2017 Oct 24;4(5):ENEURO.0227-17.2017. doi: 10.1523/ENEURO.0227-17.2017

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Copyright © 2017 Clark et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Overexpression of D2R in D2R-expressing PVT neurons inhibits cocaine locomotor sensitization. A, Viral spread of AAV2/1-hSyn-DIO-D2R(L)-IRES-mVenus in all D2R-OE_PVT mice within the cocaine behavioral experiment overlaid on a single coronal image (1.2 mm posterior to bregma). B, Illustration of the cocaine locomotor sensitization behavioral design. C, D2R-OE_PVT mice receiving cocaine injections exhibited decreased locomotion for the first 15 min on day 14, the cocaine challenge day, when compared to control EGFP_PVT mice receiving cocaine injections (RM ANOVA over days 1–14: F_{groupxday(3,24)} = 8.6, p < 0.0001; post hoc Bonferroni D2R-OE_PVT vs EGFP_PVT on day 14 *p < 0.05, n = 7-8/group). D, D2R-OE_PVT mice receiving cocaine injections exhibited decreased locomotion immediately after the injection when analyzed over the entire 180-min period (RM ANOVA: F_{groupxtime(3105)} = 1.82, p < 0.0001, Bonferroni post hoc: ***p < 0.001 for 20th 5-min time bin for D2R-OE_PVT vs EGFP_PVT with cocaine, n = 7-8/group). PVT, paraventricular nucleus of the thalamus.