Table 1.
Genotype association between SNP in ESR-α gene and knee osteoarthritis.
| All subjects | Women | Men | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Control (%) | Case (%) | OR, (95% CI), p value | Control (%) 276 |
Case (%) 295 |
OR, (95% CI), p value | Control (%) 224 | Case (%) 205 |
OR, (95% CI), p value | |
| Genotype | |||||||||
| BtgI (rs 2228480) | |||||||||
| GG | 231 (46.20) | 170 (34.00) | 1.00, (Ref) | 127 (46.01) | 94 (31.86) | 1.00, (Ref) | 104 (46.24) | 76 (37.07) | 1.00, (Ref) |
| GA | 218 (43.60) | 259 (51.8) | 1.61, (1.23–2.11), 0.000∗ | 120 (43.47) | 158 (53.55) | 1.77, (1.24–2.54), 0.001∗ | 98 (43.75) | 101 (49.26) | 1.41, (0.94–2.11), 0.096 |
| AA | 51 (10.20) | 71 (14.2) | 1.89, (1.25–2.85), 0.002∗ | 29 (10.50) | 43 (14.57) | 2.00, (1.16–3.44), 0.011∗ | 22 (09.82) | 28 (13.65) | 1.74 (0.92–3.27), 0.083 |
|
| |||||||||
| Allele | |||||||||
| BtgI (rs 2228480) | |||||||||
| G | 680 (68.0) | 599 (59.9) | 1.00, (Ref) | 374 (67.75) | 346 (58.64) | 1.00, (Ref) | 306 (68.30) | 253 (61.70) | 1.00, (Ref) |
| A | 320 (32.0) | 401 (40.1) | 1.42, (1.18–1.70), 0.000∗ | 178 (32.24) | 244 (41.35) | 1.48, (1.16–1.88), 0.001∗ | 142 (31.69) | 157 (38.29) | 1.33, (1.00–1.77), 0.042∗ |
OR, odds ratio; 95% CI, 95% confidence interval; Ref, reference category; ∗p < 0.05 is considered statistically significant.