Table 2.
Genotype association between 3 SNPs in CALM-1 gene and knee osteoarthritis.
| All subjects | Women | Men | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Control (%) 500 |
Case (%) 500 |
OR, (95% CI), p value | Control (%) 276 |
Case (%) 295 |
OR, (95% CI), p value | Control (%) 224 | Case (%) 205 |
OR, (95% CI), p value | |
| Genotype | |||||||||
| ApaLI (rs 12885713) | |||||||||
| CC | 125 (25) | 102 (20.4) | 1.00, (Ref) | 70 (25.36) | 62 (21.01) | 1.00, (Ref) | 55 (24.55) | 40 (19.51) | 1.00, (Ref) |
| CT | 233 (46.6) | 240 (48) | 1.26, (0.91–1.73), 0.150 | 119 (43.11) | 117 (39.66) | 1.11, (0.72–1.70), 0.631 | 114 (50.89) | 123 (60.00) | 1.48, (0.91–2.39), 0.106 |
| TT | 142 (28.4) | 158 (31.6) | 1.36, (0.96–1.92), 0.078 | 87 (31.5) | 116 (42.02) | 1.50, (0.96–2.33), 0.068 | 55 (24.55) | 42 (20.48) | 1.05, (0.59–1.86), 0.867 |
|
| |||||||||
| Allele | |||||||||
| rs 12885713 | |||||||||
| C | 483 (48.3) | 444 (44.4) | 1.00, (Ref) | 259 (46.92) | 241 (40.84) | 1.00, (Ref) | 224 (50.00) | 203 (49.51) | 1.00, (Ref) |
| T | 517 (51.7) | 556 (55.6) | 1.17, (0.98–1.39), 0.080 | 293 (53.07) | 349 (59.15) | 1.28, (1.01–1.61), 0.038∗ | 224 (50.00) | 207 (50.48) | 1.02, (0.78–1.33), 0.886 |
|
| |||||||||
| Genotype | |||||||||
| ApeKI (rs 3814843) | |||||||||
| TT | 477 (95.4) | 444 (88.8) | 1.00, (Ref) | 259 (93.8) | 258 (87.45) | 1.00, (Ref) | 218 (97.32) | 186 (90.73) | 1.00, (Ref) |
| TG | 23 (4.6) | 56 (11.2) | 2.61, (1.58–4.32), 0.000∗ | 17 (6.1) | 37 (12.55) | 2.18, (1.2–3.98), 0.009∗ | 06 (2.67) | 19 (9.26) | 3.71, (1.45–9.48), 0.003∗ |
| GG | — | — | — | — | — | — | |||
|
| |||||||||
| Allele | |||||||||
| rs 3814843 | |||||||||
| T | 977 (97.7) | 944 (94.4) | 1.00, (Ref) | 535 (96.92) | 553 (93.72) | 1.00, (Ref) | 442 (98.66) | 391 (95.36) | 1.00, (Ref) |
| G | 23 (2.3) | 56 (5.6) | 2.52, (1.53–4.12), 0.000∗ | 17 (03.07) | 37 (06.27) | 2.10, (1.17–3.78), 0.011∗ | 06 (01.33) | 19 (04.63) | 3.46, (1.39–8.57), 0.004∗ |
|
| |||||||||
| Genotype | |||||||||
| rs 2300496 | |||||||||
| AA | 167 (33.4) | 147 (29.4) | 1.00, (Ref) | 86 (31.15) | 80 (27.11) | 1.00, (Ref) | 81 (36.16) | 67 (32.68) | 1.00, (Ref) |
| AC | 220 (44) | 221 (44.2) | 1.14, (0.85–1.52), 0.371 | 125 (45.28) | 132 (44.74) | 1.13, (0.76–1.67), 0.524 | 95 (42.41) | 89 (43.41) | 1.13, (0.73–1.74), 0.573 |
| CC | 113 (22.6) | 132 (26.4) | 1.32, (0.94–1.85), 0.097 | 65 (23.55) | 83 (28.13) | 1.37, (0.88–2.14), 0.162 | 48 (21.42) | 49 (23.90) | 1.23, (0.73–2.06), 0.421 |
|
| |||||||||
| Allele | |||||||||
| rs 2300496 | |||||||||
| A | 554 (55.4) | 515 (51.5) | 1.00, (Ref) | 297 (53.84) | 292 (49.49) | 1.00, (Ref) | 257 (57.36) | 223 (56.82) | 1.00, (Ref) |
| C | 446 (44.6) | 485 (48.5) | 1.17, (0.98–1.39), 0.080 | 255 (46.19) | 298 (50.50) | 1.18, (0.95–1.5), 0.145 | 191 (42.63) | 187 (45.60) | 1.12, (0.86–1.47), 0.380 |
OR, odds ratio; 95% CI, 95% confidence interval; Ref, reference category; ∗p < 0.05 is considered statistically significant.