Table 3.
Genotype association between SNP in GDF-5 (BsiE1) gene and knee osteoarthritis (KOA).
| All subjects | Women | Men | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Control (%) | Case (%) | OR, (95% CI), p value | Control (%) 276 |
Case (%) 295 |
OR, (95% CI), p value | Control (%) 224 | Case (%) 205 |
OR, (95% CI), p value | |
| Genotype | |||||||||
| BsiE1 (rs 143383) | |||||||||
| CC | 97 (19.40) | 75 (15.00) | 1.00, (Ref) | 58 (21.01) | 47 (15.93) | 1.00, (Ref) | 39 (17.41) | 28 (13.65) | 1.00, (Ref) |
| CT | 272 (54.4) | 226 (45.20) | 1.07, (0.75–1.52), 0.686 | 137 (49.63) | 117 (39.66) | 1.05, (0.66–1.66), 0.821 | 135 (60.26) | 109 (53.17) | 1.12, (0.65–1.94), 0.673 |
| TT | 131 (26.2) | 199 (39.80) | 1.96, (1.35–2.85), 0.000∗ | 81 (29.34) | 131 (44.40) | 1.99, (1.24–3.20), 0.004∗ | 50 (22.32) | 68 (33.17) | 1.89, (1.03–3.47), 0.038∗ |
|
| |||||||||
| Allele | |||||||||
| C | 466 (46.6) | 376 (37.6) | 1.00, (Ref) | 253 (45.83) | 211 (35.76) | 1.00, (Ref) | 213 (47.54) | 165 (40.24) | 1.00, (Ref) |
| T | 534 (53.4) | 624 (62.4) | 1.44, (1.21–1.73), 0.000∗ | 299 (54.16) | 379 (64.23) | 1.52, (1.19–1.92), 0.000∗ | 235 (52.45) | 245 (59.75) | 1.34, (1.02–1.76), 0.031∗ |
OR, odds ratio; 95% CI, 95% confidence interval; Ref, reference category; ∗p < 0.05 is considered statistically significant.