Fig 2. Time taken for a clone initiated from a single HSC to expand under different levels of selection.

(a) Time taken for a mutant clone to expand as a function of the level of clonality reached, with colour indicating the selective effect of the mutant. (b) Time taken for a mutant clone to expand as a function of the selective effect, with colour indicating different levels of clonality. Symbols are results from 10³ simulations of the full model (with associated standard deviations), and solid lines are predictions from Eq (6). Shaded regions are the predicted standard deviations, using the formula presented in the S1 Supporting Information. Here ℓ = 3 minutes, s* = 100, and the remaining parameters are as in Table 1.