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Kinetic models. From top to bottom: 1-tissue compartment model (1TCM), 2-tissue compartment model with irreversible uptake (irr2TCM), and 2TCM with reversible uptake (rev2TCM). The rate constants were fitted as K1 (unit mL/min/cm3 or mL/min/100 cm3), the ratio K1/k2 (unit mL/cm3), k3 (unit min−1), and the ratio k3/k4 (no unit). Also the blood fraction Vb was fitted.
