Table 1.
BMI <18.5 | 18.5 ≤ BMI < 25 | 25 ≤ BMI < 30 | 30 ≤ BMI < 35 | BMI ≥ 35 | p-value | |
---|---|---|---|---|---|---|
N= 84 | N= 983 | N= 1,368 | N= 1,028 | N= 393 | ||
Age | 43 (15.5–57) | 56 (45–63) | 57 (48–63) | 55 (45–61) | 49 (40–57) | <0.0001 |
Male (%) | 44 (52.4) | 716 (72.8) | 1,086 (79.4) | 827 (80.5) | 281 (71.5) | <0.0001 |
ICM (%) | 17 (20.2) | 390 (39.7) | 691 (43.2) | 425 (41.3) | 138 (35.1) | <0.0001 |
Race (%) | <0.0001 | |||||
White | 43 (51.2) | 618 (62.9) | 957 (70.0) | 674 (65.6) | 222 (56.5) | |
Black | 28 (33.3) | 240 (24.4) | 289 (21.1) | 260 (25.3) | 144 (36.6) | |
Device Type (%) | <0.0001 | |||||
Heartmate II | 49 (58.3) | 797 (81.1) | 1,179 (86.2) | 887 (86.3) | 333 (84.7) | |
Heartware HVAD | 35 (41.7) | 186 (18.9) | 189 (13.8) | 141 (13.7) | 60 (15.3) | |
GFR (MDRD) | 101.1 (66.8–135.0) | 75.9 (52.8–89.0) | 64.8 (50.4–84.1) | 62.8 (47.8–78.7) | 61.7 (46.9–78.2) | <0.0001 |
CrCl (Cockcroft-Gault) | 73.2 (54.3–98.8) | 73.2 (54.3–93.9) | 73.5 (56.7–95.0) | 66.8 (52.2–87.4) | 67.6 (51.8–87.4) | <0.0001 |
Adj Body Wt CrCl | 73.2 (54.3–98.8) | 73.2 (54.3–93.9) | 76.7 (59.5–99.3) | 76.2 (59.4–97.9) | 82.1 (62.5–107.4) | <0.0001 |
Creatinine (mg/dL) | 0.9 (0.7–1.1) | 1.1 (0.9–1.4) | 1.2 (0.9–1.5) | 1.2 (1.0–1.5) | 1.3 (1.0–1.6) | <0.0001 |
Dialysis (%) | 2 (2.4) | 33 (3.4) | 32 (2.3) | 38 (3.7) | 12 (3.1) | 0.37 |
Hemodynamics | ||||||
mPAP (mmHg) | 30 (25–37) | 30 (22–37) | 30 (22–38) | 31 (23–39) | 33 (25–42) | <0.0001 |
PCWP (mmHg) | 23 (15–28) | 20 (12–27) | 20 (13–27) | 20 (14–27) | 22 (16–29) | 0.0008 |
PVR (WU) | 2.55 (1.79–4.23) | 2.45 (1.59–3.61) | 2.27 (1.45–3.33) | 2.24 (1.43–3.24) | 2.11 (1.37–3.01) | <0.0001 |
CO (L/min) | 2.9 (2.4–3.8) | 3.8 (3.1–4.7) | 4.3 (3.5–4.2) | 4.6 (3.7–5.5) | 4.9 (4.0–5.8) | <0.0001 |
CI (L/min/m2) | 1.87 (1.61–2.42) | 2.12 (1.73–2.56) | 2.13 (1.74–2.55) | 2.08 (1.70–2.50) | 2.09 (1.74–2.45) | 0.12 |
Diabetes (%) | 6 (7.1) | 179 (18.3) | 438 (32.0) | 435 (42.5) | 173 (44.0) | <0.0001 |
ICD (%) | 51 (60.7) | 726 (74.0) | 1,092 (79.9) | 833 (81.3) | 326 (83.0) | <0.0001 |
Prior Smoker (%) | 26 (31.0) | 458 (46.8) | 749 (54.9) | 567 (55.5) | 193 (49.4) | <0.0001 |
Prior Stroke (%) | 4 (4.8) | 54 (5.5) | 84 (6.2) | 60 (5.9) | 15 (3.8) | 0.28 |
Transplanted (%) | 59 (70.2) | 742 (75.5) | 988 (72.2) | 706 (68.7) | 228 (58.0) | <0.0001 |
Data presented as Count (%) or Median (interquartile range). BMI=Body Mass Index; CrCl=Creatinine Clearance in mL/min; CI=Cardiac Index; GFR=Glomerular Filtration Rate in mL/min/1.73 m2; ICD=Implantable Cardioverter Defibrillator; ICM=Ischemic Cardiomyopathy; mPAP=Mean Pulmonary Artery Pressure; PCWP=Pulmonary Capillary Wedge Pressure; PVR=Pulmonary Vascular Resistance