Table 1.
Clinical and experimental characteristics of DIPG cell lines
| NEM157 | NEM163 | NEM165 | NEM168 | |
|---|---|---|---|---|
| Clinical characteristics | ||||
| Age at diagnosis, y | 5.7 | 5.7 | 3.3 | 10.6 |
| Sex | F | M | M | F |
| Histological diagnosis | Oligoastrocytoma | Oligoastrocytoma | Oligoastrocytoma | Astrocytoma |
| Grade | II | II | III | III |
| Time to progression, mo | 10.3 | 8.5 | 16.9 | 7.0 |
| Survival, mo | 12.9 | 10.6 | 23.9 | 8.4 |
| In vitro characteristics | ||||
| Doubling time | 30 h | 36 h | 32 h | 34 h |
| PDGFRA activation | + | ++ | ++ | +++ |
| Src activation | + | ++ | ++ | + |
| Histone Mutation | K27M H3F3A | K27M H3F3A | K27M H3F3A | K27M H3F3A |
| P53 status | Δ337–340 R273C | Wild type | Wild type | Δ156 |