Table 1.

Hazard ratios in different time intervals from randomization

		0–24 mo		>24 mo
		HR (95% CI)	P	HR (95% CI)	P
OS	RPA class
	III	–	–	–	–
	IV	1.64 (1.30, 2.08)	<.0001	1.27 (0.79, 2.05)	.33
	V	2.91 (2.21, 3.82)	<.0001	1.69 (0.79, 3.65)	.18
	Radiation type
	USA	–	–	–	–
	European	0.98 (0.80, 1.22)	.88	0.88 (0.44, 1.76)	.71
	MGMT status
	Methylated	–	–	–	–
	Unmethylated	1.78 (1.46, 2.17)	<.0001	1.52 (0.94, 2.45)	.09
	Treatment
	Standard dose	–	–	–	–
	Dose dense	1.03 (0.88, 1.22)	.70	0.99 (0.65, 1.50)	.97
		0–6 mo		>6 mo
		HR (95% CI)	P	HR (95% CI)	P
PFS	RPA class
	III	–	–	–	–
	IV	1.31 (1.00, 1.71)	.05	1.68 (1.28, 2.21)	.0002
	V	1.89 (1.38, 2.59)	<.0001	2.35 (1.65, 3.36)	<.0001
	Radiation type
	USA	–	–	–	–
	European	0.82 (0.63, 1.07)	.14	0.98 (0.75, 1.29)	.90
	MGMT status
	Methylated	–	–	–	–
	Unmethylated	1.47 (1.17, 1.86)	.001	1.80 (1.42, 2.27)	<.0001
	Treatment
	Standard dose	–	–	–	–
	Dose dense	0.70 (0.58, 0.86)	.0005	1.12 (0.90, 1.38)	.32