Table 1.
Summary of seizure outcome after radiotherapy
| Article | Study Design | Population (baseline) | Treatment | Additional Treatment, n | Time of Seizure Assessment | Seizure Outcome (% total population) |
|---|---|---|---|---|---|---|
| Rossi et al, 198528 | N/S | Malignant brain tumor and medically intractable epilepsy 15: PA 1/A 9/OA 2/O 2/AA 2 | 125I brachytherapy | None | N/S | Reduction in seizure frequency: 15/15 (100%) Seizure freedom: 8/15 (53%) |
| Rogers et al, 199327 | Retrospective | LGG and medically intractable epilepsy 5 | Focal fractionated irradiation | None | N/S | >90% Seizure reduction: 3/5 (60%) 75%–90% Seizure reduction: 1/5 (20%) Seizure freedom: 1/5 (20%) |
| Scerrati et al, 199431 | Prospective | Grade I/II glioma 36 (34 with history of epilepsy): PA 2/A 23/O 11 |
Interstitial brachytherapy | None | 12 m after therapy | Seizure freedom: 19/34 (56%) |
| Warnke et al, 199733 | Retrospective | WHO grade II astrocytoma with a history of epilepsy 80; 22 (28%) with seizure freedom | Interstitial radiosurgery with 125I temporary implants | None | 3 m after therapy 6 m after therapy |
Increase in percentage of patients with: Seizure freedom (from 28% to 68%) Seizure freedom (from 28% to 80%) |
| Schröttner et al, 199829 | Retrospective | Medically intractable tumor epilepsy 26: 17 LGG/9 other | Gamma knife radiosurgery | N/S | N/S | Engel class I/II: 13/24 (54%) Engel class III: 4/24 (17%) |
| Schröttner et al, 200230 | Retrospective | Mesiotemporal tumor epilepsy 19: LGG 15/GG 3/cavernoma 1 | Gamma knife radiosurgery | Resection 10/19 (53%) | N/S | Engel class I and II (significant reduction): 11/19 (58%) Engel class III (worthwhile improvement): 7/19 (37%) |
| Plathow et al, 200325 | Retrospective | WHO grade II astrocytoma 143; 52 with general seizures and 49 with focal seizures | Fractionated stereotactic irradiation | Complete resection: 26/143(18%) Subtotal resection: 40/143 (28%) |
6w after therapy | Decrease in percentage of patients with: Generalized seizures (from 36% to 7%) Focal seizures (34% to 17%) |
| Shankar and Rajshekhar, 200326 | Both retrospective and prospective | Insular low-grade astrocytoma 30 (26 presented with epilepsy) | Radiotherapy (unspecified) | None | N/S | Engel class I: 21/30 (70%) Engel class II: 4/30 (13%) Engel class III: 1/30 (3%) |
| van den Bent et al, 200532 | Prospective | (1) Glioma 157: A 78/OA 25/O 19/PA 2/GrIII 20/other 13 (2) glioma 154: A 80/OA 15/O 23/PA 2/GrIII 28/other 6 (no significant difference in number of patients with seizure control between groups 1 and 2) |
Focal fractionated irradiation (late) Focal fractionated irradiation (early) |
Resection: 93/157 (59%) Resection: 99/154 (64%) |
12 m after therapy 12 m after therapy |
Seizure freedom: 29/71 (59%) Seizure freedom: 26/102 (75%) |
| Ruda et al, 201313 | Retrospective | Glioma and medically intractable epilepsy 43: AII-III 28/OAII-III 5/OII-III 10 |
Focal fractionated irradiation | Resection: 29/43 (67%) | 3 m after therapy 12 m after therapy |
≥50% Seizure reduction: 31/43 (72%) Seizure freedom: 15/43 (35%) ≥50% Seizure reduction: 26/34 (77%) Seizure freedom: 13/34 (38%) |
Abbreviations: PA, pilocytic astrocytoma; A, astrocytoma grade II; OA, oligoastrocytoma grade II; O, oligodendroglioma grade II; AA, anaplastic astrocytoma; GBM, glioblastoma multiforme; GG, ganglioglioma; N/S, not specified; m, months.