Table 2. Predictors of appetitive hormone concentrations post-IV cocaine administration.
Potential predictors include the cardiorespiratory responses to cocaine (CRC) and subjective responses to cocaine (SRC) secondary to intravenous (IV) cocaine administration, the specific hormone’s concentration pre-IV cocaine, and cocaine concentration +15 min following IV cocaine administration.
| Post-IV Cocaine concentrations: | ||||
|---|---|---|---|---|
| GLP-1 | PYY | Insulin | Amylin | |
| Δ Heart Rate | - | 0.20 (0.62; 2.01) | - | −0.03 (−0.05; −0.03) |
| Δ Systolic Blood Pressure | - | - | - | - |
| Δ Respiratory Rate | - | - | −1.18 (−161.48; −97.45) | −0.06 (−0.24; −0.21) |
| Δ “Want Cocaine” | - | - | - | - |
| Δ “Good Drug Effect” | - | - | - | - |
| Δ “Strong Drug Effect” | - | - | - | - |
| Δ “High” | −0.32 (−0.53; 0.02) | −0.48 (−2.74; −1.82) | - | - |
| Δ “Rush” | - | - | - | 0.18 (0.46; 0.48) |
| Δ “Elated” | - | - | - | - |
| Δ “Stimulated” | - | - | - | - |
| Δ “Anxious” | 0.46 (0.02; 0.63) | - | - | −0.04 (−0.06; −0.05) |
| Specific hormone concentrations pre-IV Cocaine | 0.90 (0.36; 0.75) | 1.05 (1.04; 1.28) | 0.36 (0.09; 0.29) | 0.92 (0.73; 0.74) |
| +15 min Cocaine Concentration | - | - | −0.48 (−12.52; −3.08) | - |
Δ refers to the acute change in the specific measure −15 min prior, and +15 min following 25 mg IV cocaine administration
The values represent standardized Beta estimates and 95% confidence limits: β (95% Cl)