TABLE 2.
HRs for Offspring ADHD by Number of Days of Maternal Acetaminophen Use During Pregnancy
| All Indications | Groups of Indications for Acetaminophen Use | |||||||
|---|---|---|---|---|---|---|---|---|
| Fever and Infections | Pain Conditions | Indication Not Specified | ||||||
| No. of Mothers Reporting Each Exposure Duration / Overall No. of Observations of Use per Exposure Duration |
Adjusted HRa (95% CI) |
No. of Mothers Reporting Each Exposure Duration / Overall No. of Observations of Use per Exposure Duration |
Adjusted HRa
(95% CI) |
No. of Mothers Reporting Each Exposure Duration / Overall No. of Observations of Use per Exposure Duration |
Adjusted HRa
(95% CI) |
No. of Mothers Reporting Each Exposure Duration / Overall No. of Observations of Use per Exposure Duration |
Adjusted HRa
(95% CI) |
|
| No use | 103 017 | 1.00 | 84 304 | 1.00 | 75 019 | 1.00 | 4606 | 1.00 |
| 1 153 338 | Reference | 216 206 | Reference | 180 288 | Reference | 4639 | Reference | |
| 1–7 d | 36 899 | 0.90 (0.81–1.00) | 8752 | 0.90 (0.75–1.09) | 10 335 | 0.89 (0.76–1.04) | 19 154 | 1.30 (0.98–1.73) |
| 53 667 | 10 864 | 12 064 | 21 796 | |||||
| 8–14 d | 6434 | 1.18 (0.98–1.42) | 1021 | 1.02 (0.55–1.89) | 2653 | 1.12 (0.83–1.50) | 1949 | 1.96 (1.36–2.82) |
| 7923 | 1185 | 2925 | 2020 | |||||
| 15–21 d | 2003 | 1.35 (1.00–1.81) | 185 | 0.98 (0.24–3.95) | 1045 | 1.43 (0.96–2.14) | 441 | 1.79 (0.95–3.35) |
| 2369 | 200 | 1147 | 447 | |||||
| 22–28 d | 253 | 1.60 (0.70–3.69) | 16 | 6.15 (1.71–22.05) | 133 | 1.08 (0.34–3.39) | 61 | — |
| 283 | 17 | 138 | 62 | |||||
| 29 or more d | 1034 | 2.20 (1.50–3.24) | 72 | 2.40 (0.34–16.78) | 609 | 2.56 (1.54–4.25) | 200 | 2.13 (0.88–5.15) |
| 1395 | 75 | 772 | 212 | |||||
—, not applicable.
a
Adjusted for year of birth, maternal age, parity, comedication within each indication of use, acetaminophen use first 6 months before pregnancy within each indication of use (only reports on first trimester are adjusted), and acetaminophen use in the first 6 months postpartum within each indication of use (only reports on last trimester are adjusted). Two thousand two hundred and forty six children were diagnosed with ADHD by December 31, 2014.