Table II.

Pharmacokinetic parameter estimates of O₂ levels in Hs-766T tumors in mice dosed with NVX-108. Note these values have been normalized to tumor volume size (mm³).

NVX-108 dose mL/kg	Mouse ID	t1/2 elim. min/mm3	Tmax min/mm3	Cmax mmHg/mm3	AUC mmHg × min/mm3)	Vd mL/kg · mm3	Tumor volume mm3	Avg. blood perfusion BPU
0.3	015	0.021a	0.14	0.007	0.84	0.09	1307.5	40 ± 18
	009	0.017	0.03	0.003	0.17	0.58	863.6	236 ± 68
0.45	022	0.007	0.07	0.047	2.37	0.03	775.8	50 ± 9
	011	0.003	0.06	0.013	0.44	0.06	1088.3	80 ± 38
	012	0.002	0.02	0.017	0.22	0.07	1155.1	68 ± 18
0.6	014	0.056	0.03	0.002b	0.20b	2.84b	898.5	285 ± 201
	002	0.020	0.05	0.003b	0.09b	2.28b	800.2	59 ± 103
	020	0.098a	0.19	0.054	9.02	0.17	503.4	92 ± 26
	024	0.034a	0.11	0.037	5.05	0.06	992.8	127 ± 89
MEAN		0.02	0.08	0.005c,g	0.501c,f	0.15	931.7
				0.026d,g	1.010d,f
				0.046e,g	7.033e,f

Notes:

^avalues automatically calculated by the modeling software but not used in determining statistics;

^bvalues likely to have been caused by large fluctuations in blood perfusion thorough out measurement period (SD higher than 70%). These were not used in determining statistics;

^cat 0.3 mL/kg dose of NVX-108;

^dat 0.45 mL/kg dose of NVX-108;

^eat 0.6 mL/kg dose of NVX-108;

^fsignificant difference at p = 0.03 (ANOVA);

^gsignificant difference at p = 0.11 (ANOVA).