Table II.
NVX-108 dose mL/kg | Mouse ID | t1/2 elim. min/mm3 | Tmax min/mm3 | Cmax mmHg/mm3 | AUC mmHg × min/mm3) | Vd mL/kg · mm3 | Tumor volume mm3 | Avg. blood perfusion BPU |
---|---|---|---|---|---|---|---|---|
0.3 | 015 | 0.021a | 0.14 | 0.007 | 0.84 | 0.09 | 1307.5 | 40 ± 18 |
009 | 0.017 | 0.03 | 0.003 | 0.17 | 0.58 | 863.6 | 236 ± 68 | |
0.45 | 022 | 0.007 | 0.07 | 0.047 | 2.37 | 0.03 | 775.8 | 50 ± 9 |
011 | 0.003 | 0.06 | 0.013 | 0.44 | 0.06 | 1088.3 | 80 ± 38 | |
012 | 0.002 | 0.02 | 0.017 | 0.22 | 0.07 | 1155.1 | 68 ± 18 | |
0.6 | 014 | 0.056 | 0.03 | 0.002b | 0.20b | 2.84b | 898.5 | 285 ± 201 |
002 | 0.020 | 0.05 | 0.003b | 0.09b | 2.28b | 800.2 | 59 ± 103 | |
020 | 0.098a | 0.19 | 0.054 | 9.02 | 0.17 | 503.4 | 92 ± 26 | |
024 | 0.034a | 0.11 | 0.037 | 5.05 | 0.06 | 992.8 | 127 ± 89 | |
MEAN | 0.02 | 0.08 | 0.005c,g | 0.501c,f | 0.15 | 931.7 | ||
0.026d,g | 1.010d,f | |||||||
0.046e,g | 7.033e,f |
Notes:
values automatically calculated by the modeling software but not used in determining statistics;
values likely to have been caused by large fluctuations in blood perfusion thorough out measurement period (SD higher than 70%). These were not used in determining statistics;
at 0.3 mL/kg dose of NVX-108;
at 0.45 mL/kg dose of NVX-108;
at 0.6 mL/kg dose of NVX-108;
significant difference at p = 0.03 (ANOVA);
significant difference at p = 0.11 (ANOVA).