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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Vaccine. 2017 Oct 9;35(46):6264–6268. doi: 10.1016/j.vaccine.2017.09.069

Figure 3. Failed PCV-13 vaccine efficacy in the context of VAD.

Figure 3

(A) Bacterial titers and (B) survival are shown for PCV-13 vaccinated (N = 29–30 per group) and unvaccinated (N = 12–15 per group) VAD and control animals following challenge with pathogenic pneumococcus. All mice were infected with 106 CFU of serotype T4. Results are shown for two experiments combined. CON=control animals. Statistical significance was determined using a Mann-Whitney U test for comparisons of bacterial titers. Significant differences were observed between vaccinated and unvaccinated mice and between VAD and control mice. Significant differences in survival were evaluated using a Mantel-Cox test.