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. Author manuscript; available in PMC: 2017 Oct 24.
Published in final edited form as: Arch Toxicol. 2016 Nov 8;91(5):2245–2261. doi: 10.1007/s00204-016-1885-6

Figure 3. Panx1 channel inhibition diminishes cell injury following APAP overdosing.

Figure 3

Mice (n = 5 per group for 3 and 48 hours time points; n = 7 per group for 6 hours time point; n = 23 per group for 24 hours time point) were injected 300 mg/kg APAP or vehicle control followed by administration of 10 mg/kg 10Panx1 or saline 1.5 hours later. Sampling was performed 3, 6, 24 and 48 hours after APAP overdosing. (a) Liver sections were examined microscopically after hematoxylin/eosin staining (100x magnification) (upper panel) with quantification of necrotic areas (lower panel) around the central veins at the 24 hours time point. (b) Serum levels of ALT (left panel) and AST (right panel). Data are expressed as means ± SEM, with ***p < 0.001 and ****p < 0.0001 compared to APAP followed by vehicle administration.