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. Author manuscript; available in PMC: 2017 Oct 24.
Published in final edited form as: Arch Toxicol. 2016 Nov 8;91(5):2245–2261. doi: 10.1007/s00204-016-1885-6

Figure 5. Panx1 channel inhibition differentially affects serum and liver cytokine levels following APAP overdosing.

Figure 5

Mice (n = 22 per group and per time point) were injected 300 mg/kg APAP followed by administration of 10 mg/kg 10Panx1 or saline 1.5 hours later. Sampling was performed 24 hours after APAP overdosing. ELISA analysis of IL-1β, IL-6, IL-10, IL-18, TNFα and IFNγ were performed of liver (upper panels) and serum (lower panels) samples. Data are expressed as means ± SEM, with *p < 0.05, **p < 0.01 and ****p < 0.0001 compared to APAP followed by vehicle administration.