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. Author manuscript; available in PMC: 2017 Oct 24.
Published in final edited form as: Arch Toxicol. 2016 Nov 8;91(5):2245–2261. doi: 10.1007/s00204-016-1885-6

Figure 7. Panx1 channel inhibition alters the liver oxidative status following APAP overdosing.

Figure 7

Mice (n = 5 per group at 0, 3 and 6 hours time points; n = 12 per group for the 24 hours time point) were injected 300 mg/kg APAP followed by administration of 10 mg/kg 10Panx1 or saline (SAL) 1.5 hours later. Sampling was performed 0, 3, 6 and 24 hours after APAP overdosing. Hepatic levels of (a) GSH and (b) GSSG were measured and (c) the GSSG/GSH ratio was calculated. Data are expressed as means ± SEM, with ***p < 0.001 compared to APAP followed by vehicle administration.