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. Author manuscript; available in PMC: 2017 Oct 24.
Published in final edited form as: JAMA Oncol. 2016 Jan;2(1):29–36. doi: 10.1001/jamaoncol.2015.3709

Table 3.

Summary of LVEF at protocol specified time points and changes from baseline values

Baseline 12 weeks 6 months 1 year
N=406 % N=406 % N=406 % N=406 %
LVEF reduction from baseline
 <10% . 343 84 325 80 302 74
 10-15% . 29 7 36 9 35 9
 ≥16% . 2 < 1 5 1 7 2
 Required, not evaluated 1 . 7 1 9 2 22 5
 Not required2 . 25 6 31 8 40 10
LVEF level (%)
 Median(Range) 65 (50-81) . 64 (45-81) . 64 (45-83) . 64 (41-90)
1

For each time point, patients for whom cardiac evaluation was required but reported as not done were counted as “required but not evaluated” at that time point

2

Cardiac evaluations were not required for patients who went off protocol therapy due to non-cardiac toxicity. For patients who went off treatment before completing 1-year protocol specified therapy due to non-cardiac-toxicity reasons, assessments after the off-treatment visit were counted as “not required”.

LVEF=left ventricular ejection fraction