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. Author manuscript; available in PMC: 2018 Aug 16.
Published in final edited form as: Sci Transl Med. 2017 Aug 16;9(403):eaai7459. doi: 10.1126/scitranslmed.aai7459

Fig. 5. VU0422288 reduces the number of apneas in Mecp2+/− mice. WBP.

Fig. 5

(A) Average breath rate over 30 min in Mecp2+/+ (black) and Mecp2+/− (red) mice in response to vehicle (n = 14 and 11), VU0422288 (n = 11 and 11), and ADX88178 (n = 11 and 14) treatment. ###P < 0.001, #P < 0.05, two-way ANOVA with Student’s t test post hoc. # denotes within-genotype comparison. (B and C) Effects of vehicle, VU0422288, and ADX88178 treatment in Mecp2+/+ and Mecp2+/− mice on (B) inspiration and (C) expiration time. ###P < 0.001, #P < 0.05, two-way ANOVA with Student’s t test post hoc. (D) Quantification of apneas per 10,000 breaths in Mecp2+/+ and Mecp2+/− treated with vehicle, VU0422288, and ADX88178. *P < 0.001, #P < 0.05, two-way ANOVA with Student’s t test post hoc. (E) Sample plethysmography traces.