Skip to main content
. Author manuscript; available in PMC: 2017 Dec 14.
Published in final edited form as: Nature. 2017 Jun 14;546(7659):528–532. doi: 10.1038/nature22972

Extended Data Figure 6. Testing the effects of more prolonged dosing of M4284 and analysis of the duration of its effects.

Extended Data Figure 6

(a) Experimental design. (b) Animals treated as in panel (a) show a continued decrease in UTI89 levels in their feces (samples were processed after 3, 4, and 5 doses of M4284), and at the time of sacrifice in the cecum and colon, compared to control mice treated with vehicle alone (Control, 10% cyclodextrin). (c,d) The effects of mannoside treatment persist 5 days after M4284 exposure. Bars represent geometric mean ± SD, *p<0.05, **p<0.01 by Mann Whitney U test. n=9 mice (Control); n=10 mice (M4284), 2 biological replicates (b). n=16 mice, 3 biological replicates (d).