Table 1. Significant Risk Factors for Developing New Functional Status Morbidity and Mortality.
From Pollack MM, Holubkov R, Funai T, et al. Simultaneous Prediction of New Morbidity, Mortality, and Survival Without New Morbidity From Pediatric Intensive Care: A New Paradigm for Outcomes Assessment. Crit Care Med. Aug 2015;43(8):1699–1709
Univariate odds ratios to develop Morbidity (N=351) and Mortality (N=214) based on 7560 PICU admissions. Only statistically significant factors are shown. Non-significant factors for both morbidity and mortality within each category are detailed in the footnotes.
| Variable | New morbidity (%) |
Deat h (%) |
Odds Ratios: New Morbidity Vs. No New Morbidity (Odds Ratio (95% C.I.)) |
Odds Ratios: Death Vs. No New Morbidity (Odds Ratio (95% C.I.)) |
|---|---|---|---|---|
| Age at PICU Admission (1) | ||||
| 0 day to < 7 days | 7.10 | 11.30 | 1.93 (1.12, 3.35) | 5.12 (3.09, 8.50) |
| 7 days to < 14 days | 12.00 | 9.60 | 3.40 (1.88, 6.15) | 4.53 (2.31, 8.88) |
| Primary System of Dysfunction (2) | ||||
| Respiratory | 4.40 | 2.20 | 0.88 (0.55, 1.39) | 0.24 (0.16, 0.37) |
| Cancer | 5.70 | 2.50 | 1.16 (0.60, 2.23) | 0.28 (0.12, 0.63) |
| Cardiovascular Disease - Congenital | 4.50 | 4.20 | 0.92 (0.56, 1.51) | 0.47 (0.31, 0.71) |
| Endocrine | 0 | 0.40 | <0.01 (<0.01, >999) | 0.04 (0.01, 0.30) |
| Gastrointestinal disorder | 5.70 | 3.40 | 1.18 (0.61, 2.31) | 0.39 (0.19, 0.81) |
| Musculoskeletal Condition | 3.10 | 0.30 | 0.61 (0.29, 1.30) | 0.03 (0.00, 0.24) |
| Neurologic | 7.10 | 2.40 | 1.47 (0.93, 2.34) | 0.27 (0.17, 0.43) |
| Miscellaneous | 1.80 | 1.30 | 0.34 (0.15, 0.77) | 0.14 (0.06, 0.33) |
| Intervention Category (3) | ||||
| Neurosurgery | 3.40 | 0.80 | 0.59 (0.36, 0.96) | 0.20 (0.07, 0.54) |
| Orthopedic | 2.60 | 0 | 0.45 (0.21, 0.97) | <0.01 (<0.01, >999) |
| Otolaryngology | 1.70 | 0 | 0.29 (0.14, 0.63) | <0.01 (<0.01, >999) |
| Miscellaneous | 1.60 | 1.20 | 0.27 (0.10, 0.74) | 0.31 (0.10, 0.98) |
| Acute (non-Primary) or Chronic Diagnosis of Cancer (4) | ||||
| Yes | 5.90 | 7.40 | 1.37 (0.81, 2.30) | 2.95 (1.83, 4.76) |
| Trauma (5) | ||||
| Trauma | 11.90 | 3.50 | 3.14 (2.32, 4.24) | 1.40 (0.84, 2.32) |
| Admission Source (6) | ||||
| Inpatient Unit from Same Hospital | 6.60 | 5.60 | 2.15 (1.52, 3.02) | 3.79 (2.49, 5.76) |
| Direct Admission from Referring Hospital | 7.20 | 4.90 | 2.33 (1.75, 3.09) | 3.31 (2.27, 4.83) |
| PICU Admission Status (7) | ||||
| Elective (scheduled) | 3.20 | 1.30 | 0.57 (0.44, 0.72) | 0.33 (0.23, 0.48) |
| Cardiac Arrest (8) | ||||
| Yes | 15.40 | 38.50 | 6.91 (3.88, 12.3) | 33.3 (21.3, 52.0) |
| 4-Hour PRISM Score (9) | ||||
| PRISM III (Total) | 1.11 (1.09, 1.13) | 1.23 (1.21, 1.25) | ||
| PRISM III Cardiovascular Variables | 1.12 (1.06, 1.20) | 1.44 (1.37, 1.52) | ||
| PRISM III Metabolic Variables | 1.16 (1.12, 1.21) | 1.35 (1.30, 1.41) | ||
| PRISM III Chemistry Variables | 1.14 (1.07, 1.21) | 1.46 (1.38, 1.55) | ||
| PRISM III Hematological Variables | 1.16 (1.10, 1.23) | 1.39 (1.32, 1.46) | ||
| PRISM III Neurological Variables | 1.17 (1.13, 1.21) | 1.30 (1.27, 1.34) |
Reference is Age >= 144 months. Non-significant age categories were 14 days to < 21 days, 21 days to < 1 month, 1 month to < 12 months, 12 months to < 60 months, 60 months to < 144 months.
Reference is acquired cardiovascular disease. Non-significant systems of dysfunction were hematological and renal.
Intervention Category. Reference is no intervention. Non-significant intervention categories included cardiovascular surgery, interventional catheterization, and general surgery.
Cancer. Reference is no acute or chronic cancer.
Trauma. Reference is no trauma.
Admission Source. Reference is operating room or post-anesthesia care unit. Non-significant categories are admissions from the emergency department of the same hospital.
Admission Status. Reference is emergency.
Cardiac Arrest. Reference is no cardiac arrest.
PRISM. Data shown are for each change of one PRISM point.