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. Author manuscript; available in PMC: 2017 Oct 24.
Published in final edited form as: Transplantation. 2013 Jul 27;96(2):217–223. doi: 10.1097/TP.0b013e31829807aa

TABLE 2.

HSCT characteristics and C4d staining of kidney tissue

ID Diagnosis HSCT type Conditioning regimen Cause of death Renal pathology findings PTC C4d stain Arteriolar C4d stain Glomerular C4d stain Tubular BM C4d stain
TA-TMA group
1 NB Auto MA Alive at last follow-up TMA Rare Diffuse Focal
2 NB Auto MA Alive at last follow-up TMA Diffuse Diffuse
3 MB Auto MA Alive at last follow-up TMA Rare Focal Rare Rare
4 AMT Allo MA Alive at last follow-up TMA Focal
5a NB Auto MA Relapsed NB TMA Rare Diffuse
6 NB Auto MA TA-TMA TMA Rare
7 HLH Allo RIC TA-TMA TMA Focal
8 NB Auto MA Alive at last follow-up TMA Rare Diffuse Focal Focal
Control group
1 XLP Allo RIC Necrotizing encephalopathy GS/TA Focal
2 FA Allo MA ARDS/adenoviral infection TN Rare
3 HLH Allo RIC Pulmonary hypertension Normal Focal
4 CID Allo RIC Pseudomembranous colitis ↑ Vascular CT Diffuse
5 WAS Allo RIC ARDS TA/IF Focal Diffuse
6 XLP Allo RIC Adenoviral infection GS/TA Focal
7 HLH Allo RIC Chronic GVHD Abscesses Focal
8 IPEX Allo RIC Septic shock Normal Rare
9 HLH Allo RIC Disseminated fungal infection TN Focal
10 HLH Allo MA Adenoviral infection TN
11 ALL Allo MA Sepsis/relapsed leukemia Normal Rare
12 EWS Auto MA ARDS/relapsed EWS Infarcts
a

Both biopsy and autopsy with similar findings.

Diffuse if >50% tissue staining, focal if 10% to 50% of tissue, rare if 1% to 10% of tissue, or negative (—) if 0%.

ALL, acute lymphoblastic leukemia; Allo, allogeneic HSCT; AMT, amegakaryocytic thrombocytopenia; ARDS, acute respiratory distress syndrome; Auto, autologous HSCT; BM, basement membrane; CID, combined immunodeficiency; CT, connective tissue; EWS, Ewing sarcoma; FA, Fanconi anemia; GS, glomerular sclerosis; GVHD, graft-versus-host disease; HLH, hemophagocytic lymphohistiocytosis; IF, interstitial fibrosis; IPEX, immunodysregulation polyendocrinopathy enteropathy X-linked syndrome; MA, myeloablative; MB, medulloblastoma; NB, neuroblastoma; PTC, peritubular capillary; RIC, reduced intensity conditioning; TA-TMA, transplant-associated thrombotic microangiopathy; TA, tubular atrophy; TN, tubular necrosis; WAS, Wiskott-Aldrich syndrome; XLP, X-linked lymphoproliferative disease.