Skip to main content
. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Cancer Res. 2017 Aug 15;77(19):5228–5235. doi: 10.1158/0008-5472.CAN-17-0320

Figure 3.

Figure 3

CPSF complex alterations in prostate cancer. A. Enrichment analysis of a set of 91 genes involved in mRNA 3′ end processing in 52 tumor/matched normal TCGA RNA-seq samples. B. Oncoprints depicting CPSF core complex gene alterations in primary and metastatic prostate cancer (12,13). C. AR and AR-V mRNA levels in 22Rv1-undup3 cells transfected with siRNAs targeting CPSF core complex genes, relative to 18S internal control. Bars represent means (n=6, error bars = 95% confidence intervals. **** p≤0.0001, ** p ≤ 0.01, ns p>0.05, unpaired t-test. D. Heatmap of log2 fold changes in mRNA expression of CPSF core complex factors in primary prostate cancer compared to normal tissue (52 matched samples).