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. Author manuscript; available in PMC: 2018 Jan 14.
Published in final edited form as: Science. 2017 Jul 14;357(6347):204–208. doi: 10.1126/science.aal1962

Fig. 2. NrHV clearance in immune-competent mice is associated with a strong intrahepatic antiviral immune response.

Fig. 2

8-week-old C57BL/6J mice were infected i.v. with 104 GE of NrHV. (A) Viremia during acute resolving infection. (B) Flow cytometric analysis of total numbers of hepatic Ly6C+monocytes, NKp46+NK cells, CD3+CD4+ T cells and CD3+CD8+ T cells during acute infection. Dotted lines indicate baseline levels. (C–E) Flow cytometric analysis of peripheral and hepatic T cells during acute NrHV infection. Frequencies of CD44+ effector cells (C), T-bet+ cells (D) and IFN-γ producing cells (PMA/Ionomycin stimulation) (E) within the CD4+ (upper panels) and CD8+ (lower panels) T cell subsets are shown. (F) ALT levels in serum of mice. Dotted line indicates baseline level. (G) Representative H&E histology at day −1 and day 9 p.i. Scale bars, 100μm. Representative data from 2 independent experiments with 4 mice per group (mean ±SEM) are shown.