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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: Immunity. 2017 Aug 15;47(2):251–267.e7. doi: 10.1016/j.immuni.2017.07.015

Figure 7. A subset of genes with αKG-sensitive CTCF peaks have αKG-inducible gene expression in ES cells.

Figure 7

(A, B) UCSC genome browser tracks representing Hi-C PC1 analysis, CTCF ChIP-seq, or H3K27Ac ChIP-seq peaks for CD4+ Th1 cells exposed to high IL-2, low IL-2, or low IL-2 with αKG. Displayed are regions surrounding the (A) Pdgfra gene or (B) genes from differentiation pathways associated with ES and T cells. (C) Graphs representing the FPKM values from the RNA-seq analyses of CD4+ Th1 cells, E14Tg2a cells, and CD8+ Tc1 cells with 3, 4, and 4 independent biological replicates respectively. See also Fig. S7.