Table 1.
Demographic and Clinical Characteristics
| Randomized arm | 55.8 Gy(RBE) (N=22) |
63.0 Gy(RBE) (N=22) |
p-value |
|---|---|---|---|
|
| |||
| Age (years) | 0.004 | ||
| Median | 61 | 50.5 | |
| Range | 31–77 | 38–76 | |
|
| |||
| Sex | 1.000 | ||
| Female | 14 (64%) | 15 (68%) | |
| Male | 8 (36%) | 7 (32%) | |
|
| |||
| Tumor location | 0.280 | ||
| Sphenoid wing | 7 (32%) | 8 (36%) | |
| Cavernous sinus | 3 (14%) | 8 (36%) | |
| Sella/Parasella | 6 (23%) | 2 (9%) | |
| Cerebellar pontine angle | 3 (14%) | 1 (5%) | |
| Clival/prepontine space | 3 (14%) | 1 (5%) | |
| Olfactory groove | 1 (5%) | 0 | |
| Optic canal | 0 | 1 (5%) | |
| Tentorium | 0 | 1 (5%) | |
|
| |||
| Smoking status* | 0.200 | ||
| Yes | 9 (45%) | 13 (68%) | |
| No | 11 (55%) | 6 (32%) | |
|
| |||
| Comorbidities | |||
| Hypertension | 3 (14%) | 6 (27%) | 0.457 |
| Diabetes mellitus | 0 | 4 (18%) | 0.108 |
| Hyperlipidemia | 1 (5%) | 0 | 1.000 |
| Coronary artery disease | 1 (5%) | 0 | 1.000 |
| One or more of the above | 4 (18%) | 6 (27%) | 0.721 |
|
| |||
| Radiation indication | 1.000 | ||
| STR, postoperative | 11 (50%) | 12 (55%) | |
| Recurrent disease | 11 (50%) | 10 (45%) | |
|
| |||
| GTV (cc)* | 0.107 | ||
| Median | 39.7 | 13.2 | |
| Range | (5.6–243.0) | (3.0–313.0) | |
|
| |||
| CTV (cc)* | 0.237 | ||
| Median | 49.0 | 28.0 | |
| Range | (9.0–464.0) | (6.5–150.7) | |
STR, subtotal resection; GTV, gross tumor volume; CTV, clinical target volume
*
Missing data on smoking status (5 patients), GTV (4 patients), CTV (14 patients)