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. Author manuscript; available in PMC: 2018 Dec 15.
Published in final edited form as: Int J Cancer. 2017 Sep 13;141(12):2462–2470. doi: 10.1002/ijc.31019

Table 2.

Adult height, age at attained height, and age at menarche in relation to breast cancer incidence, 1995–2015.

All invasive breast cancer (n=1,826)
ER+ breast cancer (n=1,015)
ER- breast cancer (n=542)
Person-years Cases HR 95% CI Cases HR 95% CI Cases HR 95% CI
Adult height (inches)a
 ≤63 316,811 541 1.0  Ref 294 1.0  Ref 170 1.0 Ref
 64–65 288,848 516 1.08 (0.96, 1.22) 294 1.14 (0.97, 1.34) 144 0.96 (0.77, 1.20)
 66–67 264,673 464 1.09 (0.96, 1.23) 261 1.12 (0.95, 1.33) 135 1.00 (0.80, 1.26)
 68–69 119,411 196 1.09 (0.92, 1.28) 102 1.04 (0.83, 1.30) 63 1.11 (0.83, 1.48)
 ≥70 56,515 109 1.33 (1.08, 1.63) 64 1.44 (1.09, 1.89) 30 1.16 (0.78, 1.71)
 per 1-inch increase 1,046,258 1,826 1.02 (1.00, 1.04) 1,015 1.02   (1.00, 1.05) 542 1.01 (0.97, 1.04)
  P-valueb   0.04  0.04 0.77   
Age at attained height (years)a,c
 >17 142,431 201 1.0 Ref 122 1.0 Ref 55 1.0 Ref
 13–17 594,043 843 0.98 (0.84, 1.15) 499 0.96 (0.78, 1.17) 264 1.11 (0.83, 1.48)
 <13 61,203 117 1.24 (0.97, 1.57) 75 1.30 (0.96, 1.76) 34 1.25 (0.80, 1.96)
Age at menarche (years)a
 ≥14 198,945 308 1.0 Ref 164 1.0 Ref 96 1.0 Ref
 12–13 546,800 965 1.22 (1.07, 1.39) 552 1.30 (1.09, 1.55) 266 1.07 (0.85, 1.36)
 ≤11 300,514 553 1.30 (1.12, 1.50) 299 1.27 (1.04, 1.56) 180 1.37 (1.06, 1.78)
 per 1-year increase 1,046,258 1,826 0.96 (0.93, 0.99) 1,015 0.96 (0.92, 1.00) 542 0.95 (0.90, 1.00)
  P-valueb  <0.01 0.04 0.77   

ER, estrogen receptor; HR, hazard ratio; CI, confidence interval Multivariable HRs are adjusted for age, questionnaire cycle, family history of breast cancer, current BMI (continuous, kg/m2), parity/age at first birth, oral contraceptive use, menopausal status, estrogen plus progestin use, and education.

a

Models additionally include mutual adjustment for variables noted.

b

Based on continuous term in multivariable model.

c

Follow-up for this analysis begins in 1999.