Table 2.
Adult height, age at attained height, and age at menarche in relation to breast cancer incidence, 1995–2015.
|
All invasive breast cancer (n=1,826)
|
ER+ breast cancer (n=1,015)
|
ER- breast cancer (n=542)
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Person-years | Cases | HR | 95% CI | Cases | HR | 95% CI | Cases | HR | 95% CI | ||
| Adult height (inches)a | |||||||||||
| ≤63 | 316,811 | 541 | 1.0 | Ref | 294 | 1.0 | Ref | 170 | 1.0 | Ref | |
| 64–65 | 288,848 | 516 | 1.08 | (0.96, 1.22) | 294 | 1.14 | (0.97, 1.34) | 144 | 0.96 | (0.77, 1.20) | |
| 66–67 | 264,673 | 464 | 1.09 | (0.96, 1.23) | 261 | 1.12 | (0.95, 1.33) | 135 | 1.00 | (0.80, 1.26) | |
| 68–69 | 119,411 | 196 | 1.09 | (0.92, 1.28) | 102 | 1.04 | (0.83, 1.30) | 63 | 1.11 | (0.83, 1.48) | |
| ≥70 | 56,515 | 109 | 1.33 | (1.08, 1.63) | 64 | 1.44 | (1.09, 1.89) | 30 | 1.16 | (0.78, 1.71) | |
| per 1-inch increase | 1,046,258 | 1,826 | 1.02 | (1.00, 1.04) | 1,015 | 1.02 | (1.00, 1.05) | 542 | 1.01 | (0.97, 1.04) | |
| P-valueb | 0.04 | 0.04 | 0.77 | ||||||||
| Age at attained height (years)a,c | |||||||||||
| >17 | 142,431 | 201 | 1.0 | Ref | 122 | 1.0 | Ref | 55 | 1.0 | Ref | |
| 13–17 | 594,043 | 843 | 0.98 | (0.84, 1.15) | 499 | 0.96 | (0.78, 1.17) | 264 | 1.11 | (0.83, 1.48) | |
| <13 | 61,203 | 117 | 1.24 | (0.97, 1.57) | 75 | 1.30 | (0.96, 1.76) | 34 | 1.25 | (0.80, 1.96) | |
| Age at menarche (years)a | |||||||||||
| ≥14 | 198,945 | 308 | 1.0 | Ref | 164 | 1.0 | Ref | 96 | 1.0 | Ref | |
| 12–13 | 546,800 | 965 | 1.22 | (1.07, 1.39) | 552 | 1.30 | (1.09, 1.55) | 266 | 1.07 | (0.85, 1.36) | |
| ≤11 | 300,514 | 553 | 1.30 | (1.12, 1.50) | 299 | 1.27 | (1.04, 1.56) | 180 | 1.37 | (1.06, 1.78) | |
| per 1-year increase | 1,046,258 | 1,826 | 0.96 | (0.93, 0.99) | 1,015 | 0.96 | (0.92, 1.00) | 542 | 0.95 | (0.90, 1.00) | |
| P-valueb | <0.01 | 0.04 | 0.77 | ||||||||
ER, estrogen receptor; HR, hazard ratio; CI, confidence interval Multivariable HRs are adjusted for age, questionnaire cycle, family history of breast cancer, current BMI (continuous, kg/m2), parity/age at first birth, oral contraceptive use, menopausal status, estrogen plus progestin use, and education.
a
Models additionally include mutual adjustment for variables noted.
b
Based on continuous term in multivariable model.
c
Follow-up for this analysis begins in 1999.