Table 4.

Association between histopathologic findings and gene expression profiles (from logistic regression analysis). Data are listed in ascending odds ratio (OR) values for each histopathologic finding. Only associations with CI not overlapping with 1 and P < 0.05 are shown.

Pathologic traits	Gene signature	OR	95% CI	P
Size >5 cm	Boyault_G3 [25]	3.93	1.03–15.00	0.045
	Lee_Poor survival [49]	4.86	1.21–19.47	0.026
	Chiang_Proliferation [22]	5.06	1.20–21.42	0.028
	Villanueva_KRT19 [6]	6.43	1.51–27.45	0.012
	Andersen_KRT19 [27]	8.25	1.90–35.91	0.005
	Coulouarn_TGF beta [28]	8.25	1.90–35.91	0.005
Tumour grade (poorly differentiated)	Hoshida_S1 [12]	4.50	1.04–19.39	0.044
	Yamashita_EpCAM [48]	4.50	1.04–19.39	0.044
	Boyault_G3 [25]	4.71	1.18–18.86	0.028
	Lee_Poor survival [49]	5.67	1.37–23.46	0.017
	Minguez_Vascular invasion [9]	5.87	1.43–24.11	0.014
	Woo_Cholangiocarcinoma_like [26]	5.87	1.43–24.11	0.014
	Andersen_KRT19 [27]	9.90	2.18–44.98	0.003
	Coulouarn_TGF beta [28]	9.90	2.18–44.98	0.003
	Hoshida_S1/S2 [12]	10.20	2.26–46.09	0.003
	Chiang_Proliferation [22]	10.56	2.17–51.42	0.004
	Villanueva_KRT19 [6]	13.93	2.78–69.88	0.001
	Cairo_Hepatoblastoma [47]	16.33	1.75–152.80	0.014
	Novak_Met [50]	21.00	2.25–195.79	0.008