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Metagenomics and metabolomics analyses showing that lead exposure significantly alters the nitrogen metabolism of the gut bacteria, as evidenced by the perturbed key genes and metabolites (A. urease accessory protein UreE; B. creatinine amidohydrolase; C. urea; D. hydroxylamine; E. nitrite reductase [NAD(P)H]; and F. copper-containing nitrite reductase). N.D.: non-detectable.
