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. 2017 Oct 24;7:13902. doi: 10.1038/s41598-017-12584-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pre-tumor lysate treatment results in similar survival improvement as compared to dendritic cell therapy in 2 glioma mouse models. Mice were treated with autologous lysate 14 and 7 days before tumor inoculation with 5 × 10⁵ glioma cells. In the GL261 glioma model both (A) intraperitoneal and (B) subcutaneous injection of lysate (n = 16 and n = 10 respectively) were studied in comparison to PBS treatment (n = 9). (C) For the CT2A glioma model only subcutaneous lysate treatment was tested. Moreover, in the two bottom graphs (subcutaneous injection), dendritic cell therapy (n = 6) was performed and applied as a literature based control condition. For graphs (A) and (B) data of two independent experiments were pooled. Statistical significance was calculated by Log-rank test, *p < 0.05.