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. 2017 Oct 24;7:13902. doi: 10.1038/s41598-017-12584-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Combining Temozolomide and lysate in a curative treatment improves median survival of glioma-bearing mice. To introduce a curative treatment strategy, lysate injection was combined with chemotherapy (temozolomide). First 20 mg/kg body weight of temozolomide was orally administered 6 times between day 5 and 16, followed by subcutaneous lysate injection at days 21, 28 and 35. The combination of temozolomide and lysate was compared to PBS treated controls and temozolomide monotherapy. One representative experiment out of two; n = 5 in the PBS control group and n = 8 in both test conditions. Statistical significance was calculated by Log-rank test, *p < 0.05; ***p < 0.001.