Table 4.
Summary of expression of mRNA for neurexins and associated proteins
| Protein location | Expression (normalized RPKM) | 9 PCW | 11–12 PCW |
|---|---|---|---|
| Presynaptic/extracellular | High: 5–25% (40–160) | CBLN1 | NRXN1 |
| NRXN1 | NRXN2 | ||
| NRXN2 | |||
| Moderate: 25–50% (10–40) | NXPH1 | NXPH1 | |
| CBLN1 | |||
| NRXN3 | |||
| Low: 50–75% (0.4–10) | CBLN2 | CBLN2 | |
| NRXN3 | |||
| Presynaptic/intraterminal | Very high: top 5% (>160) | SNAP25 | SNAP25 |
| SYP | SYP | ||
| High: 5–25% (40–160) | CASK | CASK | |
| Postsynaptic/extracellular | Very high: top 5% (>160) | NLGN2 | NLGN2 |
| High: 5–25% (40–160) | LRRTM2 | LRRTM2 | |
| NLGN3 | NLGN1 | ||
| NLGN3 | |||
| Moderate: 25–50% (10–40) | LRRTM3 | LRRTM3 | |
| LRRTM4 | LRTMM4 | ||
| NLGN1 | NLGN4X | ||
| NLGN4X | NLGN4Y* | ||
| NLGN4Y* | |||
| Low: 50–75% (0.4–10) | LRRTM1 | LRRTM1 | |
| Postsynaptic/intracellular | Very high: top 5% (>160) | DLG4 | DLG4 |
| High: 5–25% (40–160) | SHANK1 | SHANK1 | |
| Moderate: 25–50% (10–40) | SHANK2 | SHANK2 | |
| SHANK3 | SHANK3 |
Protein location describes its location in the mature central nervous system. Extracellular means at least part of the molecule is an extracellular domain. Expression is the mean across all cortical regions. Percentage values indicate into which quartile range for all protein coding expression data the expression values fall. RPKM values are indicative and not exact. *NLGNY means from male samples only, female samples gave mean expression 0.11 range 0.07–0.45. NXPH, neurexophilin.