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. 2017 Oct 24;7:13905. doi: 10.1038/s41598-017-14440-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Unique gene expression profile in iN cells from patients with NF1. (A) Heatmap of the 31 genes that were revealed as aberrant in microarray analysis. *limma adjusted p-value < 0.05. Red indicates higher expression genes, and green indicates lower expression genes. (B) MEX3D mRNA expression level. One-way ANOVA/Tukey’s test, n = 6 each group. (C–E) BCL2, FOS, and JUN mRNA expression level, respectively. Student’s t-test, n = 6 each group. Open circles show healthy controls and filled circles and squares show NF1 patients.