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Inhibitory effects of CF/DA and their combinations on B. bovis.
| Mono and combination | CF relative mean of IC50 ± SD (µM) | DA relative mean of IC50 ± SD (µM) | ΣFICs, Interaction | |
|---|---|---|---|---|
| 5:0 | *8.24 ± 0.95 | — | ||
| 4:1 | 6.82 ± 0.77 | 0.34 ± 0.04 | 1.18 | Additive effect |
| 3:2 | 5 ± 0.9 | 0.67 ± 0.12 | 1.3 | Additive effect |
| 2:3 | 3.38 ± 1.03 | 0.99 ± 0.28 | 1.44 | Additive effect |
| 1:4 | 1.24 ± 0.11 | 1 ± 0.09 | 1.19 | Additive effect |
| 0:5 | — | *0.96 ± 0.29 | ||
*IC50 value of mono-drug.
