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Proposed chemical mechanism of sulfilimine formation by HOBr. BM‐embedded PXDN catalyzes the conversion of Br− and oxidant into HOBr within the local environment of collagen IV NC1 hexamers. Formation of sulfilimine crosslinks is proposed to proceed through the initial formation of a bromosulfonium ion (Br‐S+) at Met93, which reacts with the ɛ‐NH2 on Hyl211. This triggers debromination of Met93 and deprotonation of Hyl211 to yield the sulfilimine crosslink.
