TABLE 4.
Description of patient data features
| Class | Description of feature(s)a | Standard(s) used, if applicable (WHO or ICD-10, etc.) |
|---|---|---|
| Patient | Gender, age, ht, and wt | WHO body mass index calculated, HL7 FHIR |
| Social | Birthplace, habitation, history of alcohol and drug abuse, smoking, conviction, job status, history of imprisonment | No standards apply |
| Clinical | Symptoms, comorbidities, details of TB diagnosis (smear microscopy, rapid diagnostic test results [X-pert or Hain test], culture on liquid and solid media, DST results based on culture and nucleic acid amplification techniques, drug susceptibility/resistance profile), HIV status, cART, and records of anti-TB treatment (drugs, dosage, duration of use) | ICD-10; WHO standards; Republic Scientific and Practical Center of Pulmonology and Tuberculosis, Belarus |
| Imaging (X ray and CT) | Detailed annotated radiological image, including localization and size of pulmonary pathology, presence of inherited malformations and acquired complications and comorbidities, physiological respiratory status, and degree of contrast accumulation | Standard CXR |
| Genomic | Genomic variant data are specifically prepared for TB Portals; links to the NCBI SRA are provided when available; DNA is extracted from patient clinical samples; in some cases, genomic sequencing was retrospective (DNA from frozen and stored sputum samples was extracted for full-genome sequencing studies) |
a
cART, combined antiretroviral therapy; ICD-10, International Classification of Diseases, volume 10; HL7, Health Level Seven International; FHIR, Fast Healthcare Interoperability Resources.