FIG 8 .

Survival of wild-type UTI89 and CFT073 and their corresponding isogenic mutants in whole-blood killing assays. Survival of the mprA, Pcl-lrhA, and kpsD mutants was significantly reduced compared to the wild-type strains, UTI89 (A) and CFT073 (B), respectively, after incubation in fresh whole blood. Survival of the mprA mutant was restored upon complementation with plasmid pMprA. **, P = 0.0029 to 0.0074. Data were obtained from three independent experiments; error bars indicate standard deviations. Statistical analysis was performed using an unpaired, two-tailed t test.