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. 2017 Jul 19;2(5):295–306. doi: 10.1002/lio2.88

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© 2017 The Authors Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Metabolic pathways, myoglobin, and muscle fiber types. Muscle biopsies from the four patients with the greatest difference in lean body mass during the 12 weeks of progressive resistance training (PRT) were analyzed using mass spectrometry based proteome analysis. A. Change in enzyme expression in the pentose phosphate pathway (PPP) and glycolysis. Enzymes from the PPP seemed to be up‐regulated at week 6 compared to baseline whilst the glycolysis pathway remained unchanged. B. Changes in myoglobin and the fiber types of skeletal muscle were investigated. Type 1 (slow contraction time, low power), type 2a (moderately fast contraction time, medium power), and type 2x (fast contraction time, high power), and type 2b (very fast contraction time, very high power). A+B. Baseline values are set to 1.0 and values at week 6 and 13 are normalized accordingly. Median values and upper quartiles are presented.