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. 2017 Oct 24;7:13894. doi: 10.1038/s41598-017-14341-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The variation in neovascularization patterns after BEV administration. The histopathological images show the variation in MVD, sprouting angiogenesis, co-option and IMG at 6 days after BEV administration. Upper row, experimental group (EG), middle row, corresponding control group (CG). The lower bar graphs show the variation in corresponding neovascularization patterns after BEV administration at three time points. (a,e) CD34-positive tumor microvessel. (b,f) Tenascin-C-positive stalk representing vascular sprouting. (c,g) Tumor cells surrounding CD34-positive tubes represent vascular co-option. (d,h) CD34-positive folds across the lumens represent intussusceptive microvascular growth (red arrow). Data were represented as the means ± SD. *Indicates P < 0.05.