Table 2.
Effects of ghrelin on body composition, and levels of glucose and insulin.
| WT vh | R6/2 vh | R6/2 ghrelin | p-value# | p-value§ | |
|---|---|---|---|---|---|
| Body composition | |||||
| Fat mass (g) | 7.5 ± 0.55 | 4.79 ± 0.64 | 6.36 ± 0.54 | 0.01 | 0.26 |
| Lean mass (g) | 24.77 ± 0.31 | 20.80 ± 0.49 | 21.63 ± 0.36 | <0.0001 | 0.97 |
| Fat mass (%) | 21.87 ± 1.63 | 18.38 ± 2.22 | 22.45 ± 1.29 | 0.76 | 0.42 |
| Lean mass (%) | 78.12 ± 1.63 | 81.60 ± 2.21 | 77.57 ± 1.29 | 0.76 | 0.43 |
| Glucose metabolism | |||||
| Basal glucose (mmol/L) | 9.70 ± 0.19 | 23.69 ± 2.98 | 19.81 ± 2.60 | 0.0002 | >0.9999 |
| Basal Insulin (μg/L) | 2.31 ± 0.44 | 0.59 ± 0.15 | 1.16 ± 0.22 | 0.0007 | 0.28 |
| AUC Insulin, 0–75 min | 168 ± 29.57 | 18.85 ± 3.84 | 42.21 ± 7.79 | 0.0009 | > 0.9999 |
| HOMA-IR | 24.57 ± 4.70 | 14.19 ± 2.85 | 27.86 ± 8.35 | >0,9999 | 0,5157 |
| HOMA-β | 187.8 ± 36.79 | 21.61 ± 9.54 | 43.3 ± 9.35 | 0,0002 | >0,9999 |
The table shows the effects of ghrelin after 4 weeks of treatment. Data are expressed as mean ± SEM. Two-way ANOVA with Bonferroni post hoc test for multiple comparisons was used to analyse data. #Represents the p-value between WT and R6/2 treated with vehicle, and §represents the p-value between vehicle and ghrelin treatment in R6/2 mice. A p-value below 0.05 was considered significant.