Table 2.
Associations between CKD etiology associated SNPs and other CKD etiologies.
| SNP Characteristics | IgA | MN | SLE | T1DM | GPA | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP (Gene) | Effect allele | Chr. (Position) | Known locus | OR [95% CI] | P-value | OR [95% CI] | P-value | OR [95% CI] | P-value | OR [95% CI] | P-value | OR [95% CI] | P-value |
| rs4664308 (PLA2R1) | G | 2 (160917497) | MN | (1.04 [0.87–1.25]) | (6.5 ·10−1) | 0.45 [0.34–0.60] | 6.7 ·10 −8 | (0.83 [0.61–1.13]) | (2.5 ·10−1) | (1.36 [1.01–1.84]) | (4.4 ·10−2) | (1.03 [0.79–1.36]) | (8.1 ·10−1) |
| rs7574865 (STAT4) | G | 2 (191964633) | SLE | (0.90 [0.74–1.11]) | (3.4·10−1) | (0.96 [0.71–1.28]) | (7.6 ·10−1) | 0.53 [0.39–0.73] | 9.7 ·10 −5 | (0.85 [0.60–1.19]) | (3.4 ·10−1) | (1.02 [0.74–1.40]) | (9.2 ·10−1) |
| rs1150754 (TNXB) | T | 6 (32050758) | SLE | (1.07 [0.83–1.40]) | (5.9 ·10−1) | 2.77 [2.06–3.71] | 1.9 ·10−11 | (1.97 [1.37–2.83]) | (2.8 ·10 −4 ) | 2.53 [1.78–3.60] | 2.5 ·10 −7 | (0.94 [0.63–1.42]) | (7.7 ·10−1) |
| rs660895 (HLA-DRB1) | G | 6 (32577380) | IgA | (1.09 [0.86–1.37]) | (4.7 ·10 −1 ) | (0.60 [0.40–0.89]) | (1.2 ·10−2) | (1.15 [0.77–1.71]) | (5.1 ·10−1) | 3.00 [2.17–4.18] | 4.6 ·10 −11 | 1.81 [1.32–2.47] | 2.0 ·10 −4 |
| rs2187668 (HLA-DQA1) | T | 6 (32605884) | MN | (0.93 [0.70–1.24]) | (6.3 ·10−1) | 4.48 [3.32–6.11] | 2.4 ·10 −22 | 2.36 [1.63–3.42] | 5.9 ·10 −6 | (1.89 [1.27–2.80]) | (1.6 ·10−3) | (0.75 [0.47–1.20]) | (2.2 ·10−1) |
| rs1129740 (HLA-DQA1) | A | 6 (32609105) | SSNS | (1.04 [0.88–1.24]) | (6.4 ·10−1) | (1.69 [1.30–2.19]) | 8.4 ·10−5 | (1.21 [0.89–1.62]) | (2.2 ·10−1) | 2.13 [1.52–2.97] | 1.1 ·10−5 | (1.18 [0.91–1.54]) | (2.2 ·10−1) |
| rs9275596 (HLA-DQB1) | T | 6 (32681631) | IgA | (1.20 [1.00–1.45]) | (5.3 ·10 −2 ) | 0.52 [0.41–0.67] | 3.3 ·10−7 | (0.57 [0.41–0.77]) | (3.4 ·10−4) | (1.20 [0.87–1.66]) | (2.6 ·10−1) | (1.25 [0.94–1.67]) | (1.2 ·10−1) |
| rs9277554 (HLA-DPB1) | T | 6 (33055538) | GPA | (0.75 [0.61–0.92]) | (6.5 ·10−3) | (1.04 [0.79–1.37]) | (7.8 ·10−1) | (1.24 [0.91–1.69]) | (1.7 ·10−1) | (1.05 [0.75–1.46]) | (7.9 ·10−1) | 0.14 [0.08–0.25] | 1.7 ·10 −11 |
MN: Membranous nephropathy, IgA: IgA nephropathy, SLE: Systemic lupus erythematosus, GPA: Granulomatosis with polyangiitis, T1DM: Type 1 diabetes mellitus, OR: Odds ratio, CI: Confidence interval. Bold: significant and independent association, italic: previously known association, simple style: significant, but dependent association. Numbers in brackets (): non-significant. For independence tests see Table 3. Significance threshold was set at 2.6 × 10−4 (Bonferroni correction: α = 0.05/(38*5)).