Table 2.
Regions showing significant within group effects in Pain > No-pain image contrasts. Peak MNI effects are displayed for each effect as well as FDR corrected cluster significance values.
| Brain Regions | Lat | MNI Coordinates | t-score | k | P(FDR) | ||
|---|---|---|---|---|---|---|---|
| x | Y | z | Cluster | ||||
| Controls: Pain > No pain | |||||||
| Supplementary motor area | L/R | 0 | 3 | 66 | 4.89 | 351 | <0.001 |
| Anterior insula | L | −54 | 9 | −9 | 4.62 | 239 | <0.001 |
| Inferior frontal gyrus | L | −57 | 9 | 27 | 4.35 | ||
| Anterior insula | R | 57 | 12 | −3 | 4.38 | 54 | 0.045 |
| S/L: Pain > No pain | |||||||
| Cerebellum (VI) | R | 30 | −54 | −30 | 5.48 | 76 | 0.011 |
| Primary somatosensory cortex (1/2) | L | −54 | −30 | 51 | 5.20 | 361 | <0.001 |
| Secondary somatosensory cortex | L | −57 | −24 | 21 | 4.49 | ||
| Inferior parietal lobule | L | −50 | −33 | 18 | 3.92 | ||
| Dorsal anterior cingulate cortex | L/R | −3 | 12 | 45 | 5.07 | 136 | 0.001 |
| Primary somatosensory cortex (1) | R | 57 | −27 | 51 | 4.76 | 146 | 0.001 |
| Primary somatosensory cortex (3b) | R | 54 | −18 | 42 | 3.79 | ||
| Anterior insula | L | −33 | 12 | 0 | 4.51 | 313 | 0.001 |
| Parahippocampal gyrus | L | −21 | 5 | −21 | 4.47 | ||
| Anterior insula | R | 51 | 3 | −3 | 4.40 | 105 | 0.003 |
| Dorsal lateral prefrontal cortex | L | −30 | 45 | 27 | 4.31 | 113 | 0.002 |
| Medial prefrontal cortex | L | −20 | 39 | 39 | 3.36 | ||
| Precentral gyrus | L | −27 | 0 | 60 | 4.27 | 64 | 0.017 |
| Caudate nucleus | R | 15 | 6 | 6 | 3.96 | 69 | 0.014 |
| A/G: Pain > No-pain | |||||||
| Supplementary motor area | L/R | 0 | 3 | 66 | 5.42 | 780 | <0.001 |
| Dorsal anterior cingulate cortex | L/R | 3 | −3 | 54 | 4.34 | ||
| Inferior frontal gyrus (Opercularis) | L | −57 | 9 | 9 | 4.95 | 512 | <0.001 |
| Temporal pole | L | −48 | 12 | −9 | 4.67 | ||
| Anterior Insula | L | −45 | 3 | 3 | 4.43 | ||
| Secondary somatosensory cortex | R | −60 | −21 | 19 | 4.81 | 143 | 0.027 |
| Ventral striatum | R | 21 | 6 | −9 | 4.56 | 122 | 0.026 |
| Periaqueductal gray | R | 12 | 6 | 3 | 4.42 | ||
| Premotor cortex | L | 48 | −8 | 56 | 4.28 | 137 | 0.017 |
| Anterior insula | R | 42 | 3 | 3 | 4.21 | 100 | 0.035 |
| Secondary somatosensory cortex | L | −63 | −24 | 21 | 4.13 | 111 | 0.029 |