Table 3.
Regions showing significant between group effects for Pain vs. Pain contrasts in the responder groups relative to contrasts.
| Brain Regions | Lat | MNI Coordinates | t-score | k | p(FDR) | ||
|---|---|---|---|---|---|---|---|
| x | y | z | Clusters | ||||
| S/L Pain > Controls Pain | |||||||
| Inferior frontal gyrus | L | −42 | 24 | 33 | 4.03 | 82 | <0.001 |
| Precuneus | L/R | 3 | −75 | 51 | 5.78 | 251 | <0.001 |
| Inferior parietal lobule | L | −36 | −54 | 42 | 4.69 | 97 | 0.005 |
| Dorsomedial Prefrontal cortex | L | −27 | 51 | 12 | 4.82 | 211 | <0.001 |
| Medial Frontal cortex | L | −33 | 51 | 24 | 4.50 | ||
| Cerebellum (VI) | R | −33 | −57 | −30 | 4.26 | 56 | 0.030 |
| Superior frontal gyrus | L | −27 | 3 | 63 | 4.06 | 41 | 0.048 |
| Cerebellum (Crus 2) | L/R | −3 | −84 | −36 | 4.00 | 165 | <0.001 |
| Cerebellum (Vermis 7) | L/R | 0 | −75 | −24 | 3.42 | ||
| A/G Pain > Controls pain | |||||||
| Dorsal anterior cingulate cortex | L/R | 2 | −5 | 50 | 5.21 | 596 | <0.001 |
| Supplementary motor area | L/R | 4 | −1 | 51 | 4.62 | ||
| Inferior frontal gyrus | R | 53 | 5 | 10 | 5.13 | 116 | 0.002 |
| Dorsal lateral prefrontal cortex | L | −45 | 21 | 30 | 5.04 | 89 | <0.001 |
| Primary somatosensory cortex (1) | L | −54 | −30 | 54 | 4.97 | 178 | 0.002 |
| Primary Somatosensory cortex (2) | L | −48 | −39 | 51 | 3.65 | ||
| Cerebellum (Crus 1) | L | −42 | −69 | −24 | 4.86 | 197 | 0.003 |
| Cerebellum (VII) | −30 | −78 | −45 | 4.50 | |||
| Ventral premotor area | L | 54 | 2 | 39 | 4.81 | 69 | 0.016 |
| Anterior insula | L | −50 | 3 | −3 | 4.74 | 181 | <0.001 |
| Anterior insula | R | 48 | 18 | −12 | 4.47 | 47 | 0.050 |
| Precuneus | L/R | −5 | −55 | 51 | 4.45 | 144 | 0.032 |
| Thalamus | R | 11 | 4 | 2 | 4.29 | 108 | 0.029 |
Peak MNI effects are displayed for each effect as well as FDR corrected cluster significance values.