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. 2017 Oct 24;7:13937. doi: 10.1038/s41598-017-14266-3

Table 3.

Age-specific odds ratios of maternal obstetric complications in relation to depression.

Age, years Depressed N = 5064 Non-depressed N = 20024 Odds ratio (95% confidence interval)
n (%) n (%) Crude Adjusted
 <25 yr N 578 2311
 Hyperemesis 265 (45.9) 904 (39.1) 1.31 (1.09–1.57)** 1.29 (1.05–1.59)*
 Abortion 18 (3.1) 62 (2.7) 1.17 (0.68–1.99) 1.16 (0.63–2.13)
 Malpresentation 53 (9.2) 154 (6.7) 1.41 (1.02–1.96)* 1.48 (1.03–2.13)*
 Normal spontaneous delivery 399 (69.0) 1779 (77.0) 0.67 (0.55–0.82)*** 0.63 (0.50–0.78)***
 Cesarean Section 175 (30.3) 528 (22.9) 1.47 (1.20–1.80)*** 1.58 (1.26–1.98)***
 Intrauterine fetal death 3 (0.5) 6 (0.3) 2.00 (0.50–8.04) 1.72 (0.34–8.61)
25–34 yr N 3698 14792
 Hyperemesis 1471 (39.8) 5391 (36.5) 1.15 (1.07–1.24)*** 1.14 (1.05–1.23)**
 Abortion 127 (3.4) 370 (2.5) 1.39 (1.13–1.70)** 1.46 (1.17–1.82)***
 Malpresentation 460 (12.4) 1536 (10.4) 1.23 (1.10–1.37)*** 1.25 (1.11–1.41)***
 Normal spontaneous delivery 2237 (60.5) 9831 (66.5) 0.77 (0.72–0.83)*** 0.79 (0.72–0.85)***
 Cesarean Section 1448 (39.2) 4914 (33.2) 1.29 (1.20–1.39)*** 1.27 (1.17–1.38)***
 Intrauterine fetal death 24 (0.7) 61 (0.4) 1.58 (0.98–2.53) 1.63 (0.98–2.71)
> = 35 yr N 788 2921
 Hyperemesis 252 (32.0) 822 (28.1) 1.20 (1.01–1.42)* 1.17 (0.97–1.40)
 Abortion 20 (2.5) 82 (2.8) 0.90 (0.55–1.48) 0.93 (0.55–1.56)
 Malpresentation 109 (13.8) 411 (14.1) 0.98 (0.78–1.23) 0.99 (0.77–1.26)
 Normal spontaneous delivery 364 (46.2) 1423 (48.7) 0.90 (0.77–1.06) 0.92 (0.77–1.09)
 Cesarean Section 413 (52.4) 1482 (50.7) 1.07 (0.91–1.25) 1.04 (0.88–1.24)
 Intrauterine fetal death 10 (1.3) 20 (0.7) 1.86 (0.87–4.00) 1.88 (0.84–4.20)

Adjusted odds ratio was estimated using logistic regression controlling for geographic region, hypertension, hyperthyroidism, anemia and medication.

Interaction between age and depression was significant for Cesarean section (p = 0.03), but not for hyperemesis (p = 0.44), abortion (p = 0.25), malpresentation (p = 0.12), normal spontaneous delivery (p = 0.06) and intrauterine fetal death (p = 0.90).